中国药房2011，Vol.22Issue(19)：1743-1745,3.
五味子粗多糖提取物对大鼠肝纤维化的防治作用研究
Preventive Effects of Polysaccharides from Schisandra chinensis on Liver Fibrosis in Rats
摘要
Abstract
OBJECTIVE: To investigate preventive effects of polysaccharides from Schisandra chinensis on multiple factors-induced liver fibrosis in rats. METHODS: Rats were randomly divided into six groups: normal control group (normal saline), model group (normal saline), high-dose, medium-dose and low-dose groups (colchicine 0.1 mg· kg-1,polysaccharides from S. chinensis 400, 200, 100 mg·kg-1). Liver fibrosis model was established by intraperitoneal administration of CCh and given relevant medicine via i.g. The activities of ALT and AST in serum of rots were determined and the contents of MDA and HOP were also detected as well as the activity of SOD. The pathological change of liver tissue was observed and the semi-quantitative analysis of liver fibrosis was conducted using CIAS. RESULTS: Compared with normal group, Massion staining showed obvious liver fibrosis in model group. There was collagenic fiber and lobular disorder. The serum levels of ALT and AST and the contents of MDA and HOP increased significantly, and the activity of SOD decreased significantly(P＜0.01). Compared with model group, the serum levels of ALT and AST in treatment groups decreased significantly. The content of MDA decreased while the activity of SOD increased,there was significant difference in dose-dependent manner(P＜0.01). The percentage of HOP and collagen declined (P＜0.01).CONCLUSION: Polysaccharides from S. chinensis can relieve liver damages, lipid peroxidation and liver fibrosis关键词
五味子粗多糖/复合因素/肝纤维化Key words
Polysaccharides from Schisandra chinensis/ Multiple factors/ Liver fibrosis分类
医药卫生引用本文复制引用
许珂玉,肖建英..五味子粗多糖提取物对大鼠肝纤维化的防治作用研究[J].中国药房,2011,22(19):1743-1745,3.基金项目
辽宁省教育厅基金资助项目(2009A469) （2009A469）
