兽类学报2011，Vol.31Issue(2)：171-178,8.
炔雌醚对雄性长爪沙鼠不育效果及其可逆性
Anti-fertility effect of quinestrol in male Mongolian gerbils (Merione sunguiculatus) and its reversibility
摘要
Abstract
In this study, Mongolian gerbils were randomly divided into multi-dose treated group ( MDT group), one-dose treated group (ODT group) and control group (CK group) to explore effects of quinestrol on reproductive organs and reproduetion. The epididymides, seminal vesicles and semen quality, fertility were assessed at 15, 30, 60 and 90 days after treatment. Histopathological changes of epididymides were observed by H. E stain. Results showed that the coefficient of testes, epididymides, and seminal vesicles were significantly decreased (P ＜0. 01) at 15 or 30 days after treatment. The normal function of the sex gland was impaired, which led to significant decrease in the density and amount of live spermatozoa and reproductive rates (P ＜0. 01), as well as a significant increase of abnormal spermatozoa ( P ＜0. 01 ) in both MDT group and ODT group. Compared with the ODT group, the damage for gerbil reproduction in MDT group was more severely at 15 or 30 days after treatment ( P ＜ 0. 01 ). After 60 days of treatment withdrawal, the sex gland in treated group was normalized except for gerbil epididymides in the MDT group, while semen quality and reproductive rates were still lower than those in the control group ( P ＜ 0. 01 ). The physiological indicators were recovered by 90 days of treatment withdrawal.This indicates that quinestrol shows certain effects on reducing the fertility of male gerbil with a reversible effect after 90 days' treatment and multi-dose treatment has more effects to infertility compared with one-dose treatment.关键词
炔雌醚/长爪沙鼠/不育/可逆性Key words
Infertility/ Mongolian gerbil ( Merione sunguiculatus )/ Quinestrol/ Reversibility分类
医药卫生引用本文复制引用
沈伟,郭永旺,施大钊,王登,海淑珍..炔雌醚对雄性长爪沙鼠不育效果及其可逆性[J].兽类学报,2011,31(2):171-178,8.基金项目
"973"鼠类种群生殖调控与不育控制机理资助项日(2007CB109105) （2007CB109105）
