高等学校化学学报2011，Vol.32Issue(4)：957-963,7.
含乳糖聚电解质靶向微胶囊的层层自组装构筑
Hepatic-targeting Microcapsules Construction by Layer-by-layer Self-assembly of Lactose-branched Polyelectrolyte
摘要
Abstract
Hepatic-targeting microcapsules were constructed by layer-by-layer (LBL) self-assembly of poly ( allylamine hydrochloride) (PAH) and chemo-enzymatic synthesized poly ( vinyl lactose ester-co-sodium p-styrenesulfonate) (PLESS) containing lactose branches. Alternate deposition of PAH and PLESS was carried out on different solid surfaces such as quartz slides and CaCO3 microparticles. The self-assembly nature of the novel polyelectrolytes was investigated in detail by varying polyelectrolytes concentration, ionic strength and counteranion types. The assembly process and structure of multilayers were characterized by UV-Vis. Hollow capsules were formed after the removal of CaCO3 templates and observed by TEM. The potential targetability of the system was proved in vitro by PNA lectin recognition. Furthermore biocompatibility of the polyelectrolytes was tested by MTT assay.关键词
乳糖/层层自组装/微胶囊/肝靶向性/生物相容性Key words
Lactose/ Layer-by-layer self-assembly/ Microcapsule/ Hepatic targeting/ Biocompatibility分类
化学化工引用本文复制引用
高遐,张馥,陈志春,林贤福..含乳糖聚电解质靶向微胶囊的层层自组装构筑[J].高等学校化学学报,2011,32(4):957-963,7.基金项目
国家自然科学基金(批准号:20874086)资助. （批准号:20874086）
