高等学校化学学报2011，Vol.32Issue(4)：964-970,7.
含L-乳酸基的聚丙三醇水凝胶的合成及性能
Synthesis and Properties of Novel Polyglycerol Hydrogels Containing L-Lactic Acid Groups
摘要
Abstract
Novel pH-sensitive polyglycerol hydrogels were designed and synthesized through the reaction of epichlorohydrin (ECH) with L-lactic acid (LLA) in the presence of sodium hydroxide ( NaOH), and cetyltrimethylammonium bromide (CTAB) as a phase transfer catalyst (PTC) at room temperature, followed by hydrolysis, polymerization and cross-linking reactions. The resultant gel was characterized by 13C NMR and X-ray photoelectron spectroscopy, and it was found that incorporated LLA was bound to polyglycerol network as a pendant acidic substituent by the hydroxyl group of LLA (PGL gel). The PGL hydrogels with different LLA contents and equilibrium swelling ratios were prepared by changing the feed ratios of materials. The resuits determined by chemical titration show that under the applied conditions the efficiency of introducing the carboxyl group into polyglycerol network is ca. 87％ and the amount of LLA in the hydrogel reached to ca.17％. The swelling behavior of the hydrogels in different mediums was investigated. The results show that the hydrogels are pH-, and ionic strength-responsive. The hydrogels also have the reversible swelling/deswelling properties and exhibits modulated release of drug in response to the environment pH.关键词
聚丙三醇/L-乳酸/水凝胶/pH敏感性Key words
Polyglycerol/ L-lactic acid/ Hydrogel/ pH-Sensitivity分类
化学化工引用本文复制引用
杨小钢,刘立建,廖立琼..含L-乳酸基的聚丙三醇水凝胶的合成及性能[J].高等学校化学学报,2011,32(4):964-970,7.基金项目
湖北省自然科学基金(批准号:2009CDB408)资助. （批准号:2009CDB408）
