安徽医科大学学报2011，Vol.46Issue(8)：740-742,3.
105例非小细胞肺癌表皮生长因子受体基因突变分析
Gene mutational analysis of EGFR in 105 cases of non-small cell lung cancer
摘要
Abstract
Objective To analyze the incidence and types of mutations in epidermal growth factor receptor ( EGFR ) in patients with non-small cell lung cancer ( NSCLC ). Methods 105 cases of NSCLC tissue and 80 cases of normal lung samples were measured in this study. The way of PCR amplification and gene sequencing were used to analyze the mutation of EGFR in exon 19 and 21. Results 35 cases of mutations were found in 105 lung cancer samples, with an incidence of 33.33％. There were 42. 86％ mutation in exon 19 and 57. 14％ mutation in exon 21. Each of the mutations in exon 19 was deletion of bases, while mutation of exon 21 was point mutation. The EGFR gene in exon 19 and 21 was of wild type in the normal lung tissues detected. Conclusion 33.33％ of NSCLC patients may have EGFR mutations especially in exon 19 and 21.关键词
癌,非小细胞肺/表皮生长因子受体/突变Key words
carcinoma,non-small cell lung/ receptor,epidermal growth factor/mutation分类
医药卫生引用本文复制引用
张志红,倪琛琛,于敏,杨青,许晓兰,朱莹莹..105例非小细胞肺癌表皮生长因子受体基因突变分析[J].安徽医科大学学报,2011,46(8):740-742,3.基金项目
安徽医科大学中青年学术骨干[编号:校人字(2009)38] （2009）
