中国医科大学学报2011，Vol.40Issue(3)：255-258,261,5.DOI:CNKI:21-1227/R.20110328.1518.019
高血压病患者脉压指数与血管内皮功能相关性分析
Correlation between Pulse Pressure Index and Endothelial Function in Patients with Hypertension
雷莹 1于晓玲 2陈杭 1许红1
作者信息
- 1. 金华市中心医院心二科,浙江金华321000
- 2. 辽宁医学院附属第一医院心内科,辽宁,锦州,121001
- 折叠
摘要
Abstract
Objective To study the relationship between pulse pressure index (PPI) and endothelial function in patients with hypertension,and to explore the clinical significance of PPI in the therapy of hypertension.Methods In this stuy, 120 patients with hypertension were enrolled.The systolic blood pressure,diastolic blood pressure,body mass index,fasting plasma glucose,total cholesterol,triglyceride, high-density lipoprotein-C,low-density lipoprotein-C,serum creatinine,and blood urea nitrogen were determined.The endothelin-1 (ET-1), nitric oxide (NO), and yon Willebrand factor (vWF) were measured.The flow-mediated dilatation (FMD) and nitroglycerin-mediated dilatation (NMD) were examined.The patients were divided into 4 groups according to PPI,and the differences among these groups were analyzed.Results After adjusting for age, the analysis of covariance indicated that ET-1, ET- 1/NO, and vWF increased and NO and FMD decreased with the increase of PPI and that no significant difference in NMD was found.The linear correlation analysis showed that both pulse pressure (PP) and PPI were positively correlated with ET,ET/NO,and vWF and negatively correlated with NO and FMD.Conclusion Both PP and PPI are closely correlated with endothelial function.PPI is an indicator that is more closely correlated with endothelial function and could guide the therapy of hypertension.关键词
脉压指数/内皮功能/高血压病Key words
pulse pressure index/ endothelial function/ hypertension分类
医药卫生引用本文复制引用
雷莹,于晓玲,陈杭,许红..高血压病患者脉压指数与血管内皮功能相关性分析[J].中国医科大学学报,2011,40(3):255-258,261,5.
