逯彩虹 1李保红 2李小斌 2王海波 2刘丽宁 2戴卫红 3李萍2
作者信息
- 1. 白求恩军医学院外科教研室,石家庄050000
- 2. 解放军260医院院办公室.石家庄050041
- 3. 解放军白求恩国际和平医院药剂科,石家庄050000
- 折叠
摘要
Abstract
Objective To study the distribution characteristics of lactobacillus and common pathogens in the vaginal mucosa and their relationship with cervical cancer. Methods The planting density of lactobacillus and the detection rates of common pathogens including mycete,hacterial vaginosis (BV),mycoplasma,chlamydia,infusorian,gonococcus,and human papillomavirus (HPV) 16/18 in the vaginal mucosa were determined in 65 cases of normal cervix,70 chronic cervicitis,110 cervical intraepithelial neoplasia (CIN),and 142 cervical cancer. The distribution characteristics of lactohacillus and common pathogens in the vaginal mucosa and their relationship with cervical cancer were analyzed. Results In CIN and cervical cancer groups,the planting density of lactobacillus in the vaginal mucosa gradually decreased (P ＜ 0.01 ),and the detection rates of mycete,infusorian,mycoplasma,chlamydia,bacterial vaginosis,and HPV gradually increased (P ＜ 0.01 ). In normal cervix,chronic cervicitis,and CIN groups,the detection rates of mycete,infusorian,mycoplasma,chlamydia,BV,and HPV were significantly higher in subgroup without lactobacillus infection than in subgroup with lactobacillus infection (P ＜ 0.01 ). The planting density of lactobacillus in the subgnup with infection in cervical cancer and CIN groups were significantly lower than that in chronic cervicitis and normal cervix groups (P ＜ 0.01 ). In normal cervix,chronic cervicitis,and CIN grups,the planting density of lactobacillus in subgroup with infection was signficantly lower than that in subgroup without infection (P ＜ 0.01 ); and there was no significant difference in cervical cancer group. Compared with normal cervix and chronic cervicifis groups,the negative rates of lactobacillus were signficantly higher in subgroup with HPV infection in cervical cancer and CIN groups (P ＜ 0.01 ). The planting density of lactobacillus in subgroup with HPV and lactobacillus infection in cervical cancer and CIN groups was significantly lower than that in normal cervix and chronic cervicitis groups (P ＜ 0.01 ). The detecfon rates of HPV16/18 and BV significantly increased and the detection rates of mycoplasma,chlamydia,mycete,and infusorian moderately increased in CIN and cervical cancer groups. The detection rate of gonococcus was low in each group. Conclusion L actobacillns can inhibit the proliferation and infection of common pathogens in the vaginal mucosa and prevent the abnormal proliferation and cancerization of cervical epithelial cells. The development of cervical cancer is associated with the decreased number of lactobacillus and the imbalance of vaginal flora.关键词
乳酸杆菌/宫颈癌/宫颈上皮内瘤变/人乳头瘤状病毒Key words
lactobacillus/ cervical cancer/ cervical intraepithelial neoplasia/ human papillomavirus分类
医药卫生
