动物营养学报2011，Vol.23Issue(6)：1027-1034,8.DOI:10.3969/j.issn.1006-267X.2011.06.021
三聚氰胺和三聚氰酸对蛋鸡毒性效应的研究
Toxicity of the Combination of Melamine and Cyanuric Acid on Laying Hens
摘要
Abstract
The study was conducted to investigate the toxicity of melamine (MEL) alone and the combination of MEL and cyanuric acid (CYA) on laying hens. A total of 126 Rohman 78-week-old laying hens were randomly allotted to 7 groups with 9 replicates per group and 2 birds per replicate for 35 days. Group 1 (control)were fed a basal diet, groups 2 to 4 were fed basal diets supplemented with 5, 15, and 30 mg/kg MEL, respectively, and groups 5 to 7 were fed the diets of groups 2 to 4 supplemented with 1. 667, 5, and 10 rmg/kg CYA, respectively. The MEL to CYA ratio was kept constant as 3:1 for the diets of groups 5 to 7. The results were shown as follows: 1 ) MEL and CYA supplementation significantly increased the content of UA on d 21.Moreover, UA content was higher when MEL and CYA were supplemented together; histological examination indicated that MEL had little impact on liver but damaged kidney in varying degrees; the liver and kidney of the hens fed the diets supplemented with MEL and CYA in the same time were damaged more heavily than those of the hens fed the diets supplemented with only MEL: hepatic cells disorder with abnormal lobular architecture, unclear hepatic cord and large numbers of irregular or round vacuole in liver cytoplasm were observed in the liver, and swelling epithelial cells in renal tubule, blister denaturation and even light congestion of partial glomerulus were observed in the kidney. 2 ) After elimination of MEL and CYA for 7 days, the contents of serum UA and kidney MDA recovered to the control levels, and no significant lesions in the liver and kidney were observed. In conclusion, the supplementation of MEL at 5 to 30 mg/kg and CYA at 1. 667 to 10 mg/kg can destroy the liver and kidney of laying hens; supplementation with MEL and CYA in the same time can lead to heavier damages to the liver and kidney than supplementation with MEL alone; the harmful effects of MEL and CYA can be eliminated in 7 days after withdrawal. [ Chinese Journal of Animal Nutrition, 2011, 23(6):1027-1034 ]关键词
三聚氰胺/三聚氰酸/蛋鸡/健康Key words
melamine/ cyanuric acid/ laying hens/ health分类
农业科技引用本文复制引用
张定华,白世平,张克英,丁雪梅,吴彩梅..三聚氰胺和三聚氰酸对蛋鸡毒性效应的研究[J].动物营养学报,2011,23(6):1027-1034,8.基金项目
四川省教育厅科研重点项目(08ZA071) （08ZA071）
现代农业产业技术体系项目(CARS-41) （CARS-41）
四川农业大学双支计划团队项目 （）
