广东医学2011，Vol.32Issue(15)：1953-1955,3.
钠离子对幼年期雌性大鼠骨骼生长的影响
The effects of sodium intake on bone growth in immature female rats
摘要
Abstract
Objective To study the effects and mechanism of sodium on bone growth in immature female rats.Methods Thirty - six 5 - week - old female SD rats were randomly divided into 3 groups: low dose sodium group ( LDS,0. 13％ NaCl ) , normal dose group ( NDS, 1％ NaCl ) , and high dose sodium group ( HDS, 8％ NaCl ). All doses of sodium were given orally by food for 60 days. The left tibia ( proximal tibia metaphyses, PTM ), middle ( middle part of tibia shaft. TX ) were taken for bone histomorphometry in the experiment. Results In PTM. the trabecular bone area ratio ( BV/TV ) and trabecular thickness were significantly increased in LDS group, comparing with those in HDS group ( P ＜0. 05 ). In LDS group, the bone formation rate ( BFR/TV ) was significantly increased, while the osteoclast count and surface perimeter were significantly reduced, comparing with those in NDS group ( P ＜ 0. 05 ). However, no significant difference was founded in bone formation rate , osteoclast count or suface perimeter between HDS group and NDS or LDS group.In Tx, no significant difference in cortical static parameters was revealed among the three groups. However, dynamic data showed that HDS enhanced endosteal bone resorption, which was depressed by LDS, when comparing with that in NDS group. Significant increase of endostral bone resorption and BFR were revealed in HDS group, when comparing with those in LDS group ( P ＜ 0. 05 ). Conclusion Sodium in different concentrations effects on bone growth in various patterns.LDS improves bone formation and inhibits bone resorption. However, HDS effects variously, which may he due to individual variation.关键词
骨骼/钠离子/松质骨/皮质骨/骨形态计量学Key words
bone/ sodium/ trabecular bone/ cortical bone/ bone histomorphometry引用本文复制引用
卢丽,何敬韬,陈珺,陆幸妍,程晴,高建林,蔡惠宁,李青南..钠离子对幼年期雌性大鼠骨骼生长的影响[J].广东医学,2011,32(15):1953-1955,3.基金项目
国家自然科学基金资助项目(编号:30971172) （编号:30971172）
