四川医学2011，Vol.32Issue(6)：800-802,3.
迷走神经张力与碎裂电位及房颤之间的关系研究
The relationship between vagal tone and complex fractionated atrial electrogram and atrial fibrillation
摘要
Abstract
Objective To investgate into the relationship between vagal tone and complex fractionated atrial electrogram (CFAE) and atrial fibrillation(AF).Methods 15 healthy mongrel dogs were randomly divided into three groups-A, B and C group.1mg and 5mg acetylcholine chloride (Ach) was injected into each dog in group A and B respectively,and 5ml normal saline was injected into each dog in group C.The incidence and duration of AF in the dogs of the three groups which underwent BURST stimulation after the drug injection were recorded.CFAE duration of left atrial lateral wall (point A) , left atrial posterior wall (point B) and left atrial appendage (point C ) were also recorded.Results There was no significant difference between before and after the injection of normal saline in terms of induced rate of AF in the group C.After the injection of acetylcholine, the induced rate of AF was increased significantly in group A and B respectively, but there was no significant difference between group A and B.The duration of AF in group C was shorter than that in group A and B [C vs.A: ( 7.00 ± 2.10) s vs (50.42 ± 6.36) s,P= 0.013; C vs.B: (7.00 ± 2.10) s vs ( 143.24 ± 11.28 ) s,P ＜ 0.001].The duration of AF in group B was longer than that in group A [( 143.24 ± 11.28) s vs (50.42 ±6.36) s,P ＜0.001].The CFAE duration of the sites in the left atrial lateral wall and posterior wall in group C was shorter than those in group A and B [group C, A and B: point A ( 2.2 ± 0.5 ) s vs ( 37.4 ± 6.3 ) s vs ( 132.5 ± 12.7) s, P ＜ 0.0001; point B ( 2.2 ± 0.5 ) s vs ( 37.2 ± 6.3 ) s vs ( 132.5 ± 12.7 ) s, P ＜ 0.001].CFAE could not be recorded in the point C in the left atrial appendage in group C.The CFAE duration in the group A was shorter than that in the group B[point A: (37.4 ±6.3) s vs( 132.5 ± 12.7) s,P ＜0.0001 ;point B: (37.2 ± 6.3) s vs( 132.5 ± 12.7) s,P ＜ 0.0001; point C: (35.1 ± 6.7) s vs( 130.7 ± 13.3 ) s ,P ＜ 0.0001 ).The CFAE duration of the left atrial appendage site was shorter than that of the left atrial lateral and posterior wall sites both in group A and B [group A: ( 37.4 ± 6.2) s vs ( 37.2 ± 6.3 ) s vs ( 35.1 ± 6.7 ) s, P ＜ 0.0001; group B: ( 132.4 ± 12.7 ) s vs ( 132.5 ± 12.7 ) s vs ( 130.7 ± 13.3 ) s, P ＜ 0.0001].There was no significant difference between the left atrial lateral wall and posterior wall in terms of CFAE duration [( 2.25 ± 0.5 ) s vs ( 2.25 ± 0.5 ) s, P= 0.183].Conclusion The higher the vagal tone was, the more likely the CFAE appeared and the longer the duration of AF was.关键词
迷走神经张力/心房碎裂电位/心房纤颤Key words
vagal tone/ complex fractionated atrial electrogram/ atrial fibrillation分类
医药卫生引用本文复制引用
葛正庆,雷森,周传堃,李珂,安闽生,李沂,杜荣生..迷走神经张力与碎裂电位及房颤之间的关系研究[J].四川医学,2011,32(6):800-802,3.基金项目
成都市卫生局2009年重大科技攻关课题(项目编号:0916) （项目编号:0916）
