四川医学2011，Vol.32Issue(6)：814-816,3.
VEGFR-3、LYVE-1在胃癌中的表达研究
Expression and Significance of VEGFR-3 and LYVE-1 in gastric carcinoma
刘勇 1杨继红2
作者信息
- 1. 泸州医学院病理学教研室,四川,泸州,646000
- 2. 云南天然药物药理重点实验室,云南,昆明,650031
- 折叠
摘要
Abstract
Objective To select the most specific lymphatic endothelial marker through expression between LYVE-1 and VEGFR-3 in gastric cancer. Methods The expression of CD34, VEGFR-3, and LYVE-1 was quantified in 53 sections and the normal tissues using immunohistochemistry. Micro-lymphatic vessel density ( MLD) and microvessel density ( MVD) were measured. The specificity of lymphatic vessel endothelium markers was compared hetween LYVE-1 and VEGFR-3 . Results A positive correlation was found between the number of CD34 and VEGFR-3 positive vessels ( r = 0. 387 ,P = 0. 003 ) , while a negative correlation was found between CD34 and LYVE-1 ( r = - 0. 181 ,P = 0. 232) , indicating that most VEGFR-3 vessels and few LYVE-1positive vessels were blood vessels.while most LYVE-1 positive vessels were lymphatic vessels. Thus LYVE-1 showed to be themore specific marker of lymphatic vessel endothelium. Conclusion LYVE-1 is a more specific lymphatic endothelial marker. It is also suggested that peritumoral lymphangiogenesis might promote lymph node metastasis.关键词
LYVE-1/胃癌/淋巴管密度/转移Key words
LYVE-1 / microlymphatic vessel density / metastasis / gastric carcinoma分类
医药卫生引用本文复制引用
刘勇,杨继红..VEGFR-3、LYVE-1在胃癌中的表达研究[J].四川医学,2011,32(6):814-816,3.
