中药材2011，Vol.34Issue(5)：676-679,4.
地鳖纤溶活性蛋白对荷瘤小鼠肿瘤微血管密度及血管内皮细胞生长因子表达的影响
Effect of Eupolyphaga Fibrinolytic Protein on Microvessel Density and the Expression of Vascular Endothelial Growth Factor in Mice Tumor
摘要
Abstract
Objective:To study the effect of Eupolyphaga fibrinolyric protein(EFP) on microvessel density (MVD) and the expression of vascular endthelial growth factor in transplantation S180 and H22 mice.Methods:The MVD in tumor was measured with immunohistochemical SP method and the VEGF level in serum was measured with ELISA method.Results: Compared with the control group, EFP could significantly reduce the microvessel density and decrease the expression of vascular endothelial growth factor.Conclusion: EFP has the effect of anti-angiogenesis.关键词
地鳖纤溶活性蛋白/H22细胞/S180细胞/微血管密度/血管内皮细胞生长因子Key words
Eupolyphaga fibrinolyric protein/H22 cell line/S180 cell line/Microvessel density/Vascular endothelial growth factor分类
医药卫生引用本文复制引用
曹付春,韩雅莉,陈冰,刘浩,丁鸿,黄明星,叶韵..地鳖纤溶活性蛋白对荷瘤小鼠肿瘤微血管密度及血管内皮细胞生长因子表达的影响[J].中药材,2011,34(5):676-679,4.基金项目
国家自然科学基金项目(30772739) （30772739）
广东工业大学轻工化工学院"211工程"培育项目(20091015) （20091015）
