中国临床药理学杂志2011，Vol.27Issue(6)：417-419,3.
二甲双胍联合行为干预治疗利培酮所致的代谢紊乱
Efficacy of metformin combined behavior intervention in the treatment of metabolic disorders caused by risperidone
夏金校 1王一冰 1甘建光 1曹世林 1段迪 1钱佩华 1沈妃1
作者信息
- 1. 绍兴市第七人民医院精神科,浙江,绍兴312000
- 折叠
摘要
Abstract
Objective To explore the clinical efficacy of metformin combined behavior intervention in treating metabolic disorders caused by risperidone, such as weight gain, glucose and lipid metabolism disorders.Methods A total of 150 schizophrenia patients who become obese after treated with risperidone were randomly divided into groups A (n =75) and B (n = 75).Both groups were given the same behavioral intervention for 6 months, but patients in group A also received treatment with metformin.At the point of baseline and the 6th month end, patients in both two groups received physical examination as well as a series of serological tests followed by statistic analysis.Results All the examine indexes except diastolic blood pressure, HDL -C and PRL were different between the point of baseline and the 6th month end in group A.All the examine indexes in addition to diastolic blood pressure, TC, PRL and HDL - C were different between the point of baseline and the 6th month end in group B.A lot of exam indexes were definitely different between two groups at the 6th month end, except for blood pressure, lipoprotein,AST and PRL.There were fewer adverse reactions in both two groups(P ＞ 0.05 )but mild nausea, with incidence rate of 8％ and 7％ respectively.Conclusion Both mefformin and behavior intervention play a role in the treatment of metabolic disorders caused by risperidone, while two methods combined could work better.关键词
利培酮/二甲双胍/行为干预/代谢紊乱Key words
risperidone/ metformin/ behavior intervention/ metabolic disorder分类
医药卫生引用本文复制引用
夏金校,王一冰,甘建光,曹世林,段迪,钱佩华,沈妃..二甲双胍联合行为干预治疗利培酮所致的代谢紊乱[J].中国临床药理学杂志,2011,27(6):417-419,3.
