动物学研究2011，Vol.32Issue(3)：300-306,7.DOI:10.3724/SP.J.1141.2011.03300
中老年食蟹猴群中糖尿病相关基因的表达状态
Expression status of diabetes-associated genes in middle and aged cynomolgus monkeys
摘要
Abstract
A total of 138 middle and aged cynomolgus monkeys (Macaca fascicularis) (above 10 years) were classified into three groups based on fasting plasma glucose (FPG) values, specifically low FPG, normal FPG, and high FPG group. Total cholesterol (TCHO), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), and low density lipoprotein cholesterol (LDL-C) were detected in blood by automatic biochemical analyzer The mRNA expressions of 37diabetes-associated genes were analyzed with Real-time PCR in monocytes isolated from monkey peripheral blood. No significant correlation between the four serum lipid indictors HDL-C, LDL-C, TCHO, TG and FPG (P＞0.05) were found. However, the expressions of ACE, ACLY, PRKCB1, SLC2A4, SNAP23, VAPA, IGF2BP2, and IFNG were significantly enhanc ed when FPG increased (P＜0.05).关键词
食蟹猴/血脂/外周血白细胞/糖尿病/基因表达Key words
Cynomolgus monkey/ Serum Lipid/ Peripheral blood leucocytes/ Diabetes/ Gene expression分类
医药卫生引用本文复制引用
张秀娟,李学家,夏机良,颜孙兴,季芳,张艳春,刘晓明,彭白露..中老年食蟹猴群中糖尿病相关基因的表达状态[J].动物学研究,2011,32(3):300-306,7.基金项目
国家"十二五"科技支撑计划研究项目(2011ZX093073-024) （2011ZX093073-024）
广州市重大科技专项项目(2010U1-E00811) （2010U1-E00811）
广东省自然科学基金项目(10451026001004520) （10451026001004520）
