动物学研究2011，Vol.32Issue(3)：311-316,6.DOI:10.3724/SP.J.1141.2011.03311
阿魏酸对脂多糖诱导的小鼠小胶质细胞炎性反应的抑制作用
Inhibitory effect of ferulic acid on inflammatory response in microglia induced by lipopolysaccharides
摘要
Abstract
Ferulic acid (FA) is a natural compound that expresses antioxidant and anti-inflammatory activities.Microglial cells are innate immune cells that reside within the central nervous system (CNS). Activated microglia mediated neuronal immunity contributes to the neurodegeneration associated with Alzheimer's disease. In this study, we investigated the inhibitory effect of FA on neuroinflammation in BV-2 microglial cells induced by lipopolysaccharides (LPS). Our study showed that FA significantly suppressed the production of nitric oxide (NO), prostaglandin E2 (PGE2),interleukin-1β (IL-1β), and decreased induced type Ⅱ nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2)protein in LPS-stimulated BV-2 microglia cells in a dose dependent manner. We hypothesized that this was achieved by suppressing the protein level of To11-1ike receptor 4 (TLR4).关键词
阿魏酸/脂多糖/小胶质细胞/神经性炎症/阿尔茨海默病Key words
Ferulic acid/ Lipopolysaccharides/ Microglia/ Neuroinflammation/ Alzheimer's disease分类
医药卫生引用本文复制引用
黄丰,邓华明,朱苗苗,肖飞,杨丽,张在军,肖瑛,聂红..阿魏酸对脂多糖诱导的小鼠小胶质细胞炎性反应的抑制作用[J].动物学研究,2011,32(3):311-316,6.基金项目
广东省医学科研基金项目(A2010344) （A2010344）
暨南大学药学院211工程和重点实验室创新研究项目 （）
