动物学研究2011，Vol.32Issue(3)：329-336,8.DOI:10.3724/SP.J.1141.2011.03329
大鼠眶额叶GABA及其B型受体在应激性抑郁行为发生中的作用及其影响机制
Rat orbital frontal (orbital frontal cortex, OFC) GABA B receptor mechanisms in stress and depression
摘要
Abstract
Stress-induced depression is a kind of functional and structural disability of the brain and involves many neurotransmitters and regions of the brain. A number of studies suggest involvement of γ-Aminobutyric acid (GABA) in the orbital frontal cortex (OFC) in the mechanism of stress-associated depression-like behavior in rodents. However, little work has been done on the relationship between GABA and neural plasticity of the OFC under stress. Here we exanune the effect of the GABA in the OFC during acute forced swim stress (FSS). We found remarkable depression-like behavior in FSS and an open field test (OFT), and we observed a marked decrease in Kalirin-7 expression and the basal dendritic spine density of layer V pyramidal neurons in OFC after FSS. GABA administration reversed these changes, which were inhibited by CGP3 5348, an antagonist of GABA-B receptors. These results suggest an anti-depression effect of GABA in the OFC, which may be mediated by GABA-B receptor. The anti-depression effect of GABA is related to the plasticity of the dendritic spine density. This discovery may be helpful in the development of new therapies to treat depression.关键词
强迫游泳/抑郁症/应激/Kalirin-7/γ-氨基丁酸/树突棘Key words
Forced swimming/ Depression/ Stress/ Kalirin-7/ GABA/ Spine分类
生物科学引用本文复制引用
谷朝阳,安书成..大鼠眶额叶GABA及其B型受体在应激性抑郁行为发生中的作用及其影响机制[J].动物学研究,2011,32(3):329-336,8.基金项目
中央高校基本科研业务费专项资金资助项目(GK200901011) （GK200901011）
