实用临床医药杂志2011，Vol.15Issue(7)：5-8,4.
磷酸肌酸对阿霉素引起心肌损伤大鼠体内SOD、CAT和LPO水平的影响
Study on protective effect of phosphocreatine on myocardium injury induced by adriamycin in rats
赵力 1李午生 1李凯 1李琦 1董茜 1赵羲和 1田保玲1
作者信息
- 1. 中国医科大学附属盛京医院,辽宁,沈阳,110004
- 折叠
摘要
Abstract
Objective To study the protective effect and mechanism of phosphocreatine (CP)injection on the myocardiam injury induced by adriamycin (ADR) in rats. Methods Thirty SD rats were randomly divided into three groups. The control group, normal saline was ip injected at a dose of ADR everyday. The ADR group was given ip injection of normal saline once a day for 3 days, and ADR at a dose of 3 mg/kg 30 minutes after normal saline from the 4th day, once every other day for 7 times. ADR with CP treatment group was given ip injection of phosphocreatine Na at a dose of 300 mg/kg 30 minutes after normal saline from the 4th day, once every other day for 7 times. The activities of superoxide dismutase (SOD), catalase (CAT) and the contents of lipid peroxide (LPO) in serum and myocardial were determined. At the same time, the rat myocardial pathomorphism was determined.Results CP significantly reduced the contents of LPO, and increased the activities of SOD and CAT in myocardium and serum, when ADR treated rats were intervened by CP. It is significant to compare with the ADR group (P 7＜ 0.05 ). The protection of myocardial pathological damage in therapy group was improved. Conclusion CP can inhibit myocardial lipid peroxidation induced by ADM. The mechanism maybe that CP can inhibited the activity of oxygen free radicals induced by ADM, thereby reduce the lever of LPO and protect the activities of SOD and CAT.关键词
心肌损伤/阿霉素/磷酸肌酸/脂质过氧化物/超氧化物岐化酶/过氧化氢酶Key words
injury, myocardium/ phosphocreatine/ adriamycin/ lipid peroxide/ superoxide dismutase/ catalase分类
医药卫生引用本文复制引用
赵力,李午生,李凯,李琦,董茜,赵羲和,田保玲..磷酸肌酸对阿霉素引起心肌损伤大鼠体内SOD、CAT和LPO水平的影响[J].实用临床医药杂志,2011,15(7):5-8,4.
