实用临床医药杂志2011，Vol.15Issue(7)：83-85,3.
汉防己甲素片在健康人体内的药代动力学研究
Study on the pharmacokinetics of tetrandrine tablets in healthy volunteers
董其坤1
作者信息
- 1. 山东省安丘市人民医院,山东,安丘,262100
- 折叠
摘要
Abstract
Objective To establish a high performance liquid chromato- graphic method for determination the concentration of tetrandrine in healthy volunteers. Methods The assay was conducted on the Kromasil C18 (250 mm ×4.6 mm, 5 μm) column with methanol - acetonitrile - water -glacial acetic acid (30: 15: 55: 0.8, pH 6.2) as the mobile phase. The detection wave length was set at 282 nm, and demethyltetrandrine was taken as the internal standard. Results The linearity range was 0.5 ～ 14.0 μg/mL with a regressive equation of Y = 0.0076C - 0.01875 ( r = 0.999 8 ).The recovery was above 80％, with both intra - day RSD and inter - day RSD below 10％. Conclusion The method proves to be convenient, rapid, accurate, and suitable for the pharmacokinetic study of tetrandrine and monitoring its concentration of clinical application.关键词
汉防已甲素/高效液相色谱法/药代动力学Key words
tetrandrine/ HPLC/ pharmacokinetics分类
医药卫生引用本文复制引用
董其坤..汉防己甲素片在健康人体内的药代动力学研究[J].实用临床医药杂志,2011,15(7):83-85,3.
