解放军医学杂志2011，Vol.36Issue(6)：636-638,641,4.
2型糖尿病患者血糖、血脂、氧化应激与β细胞功能的相关性研究
Correlations between blood glucose, lipid, oxidative stress and pancreatic β-cell function in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the relationship between glucose. lipid, oxidative stress and first-phase of pancreatic β-cell insulin secretion in individuals with different degrees of glucose tolerance. Methods The intravenous glucose tolerance test (IVGTT) was performed in 40 patients with newly diagnosed type 2 diabetes mellitus (DM group), 37 patients with impaired glucose tolerance (IGT group) , and 43 subjects with normal glucose tolerance (NGT group) . Glucose, lipid, fasting plasma 8-hydroxydeoxyguanosin (8-OHdG),malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) were measured. 0-10 minutes of insulin area under the curve (AUC), acute insulin response (AIR3-5, homeostasis model assessment (HOMA-IR) and homeostasis model assessment-B (HOMA-B)were calculated to analyze the relationship between oxidative stress and the fasting plasma glucose (FPG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC),AUC, AIR3-5, HOMA-B and HOMA-IR. Results SOD, AIR3-5 and AUC were significantly lower in DM and IGT group than in NGT group ( P＜0.05) ; LDL-C,TG, 8-OHdG and MDA were significantly higher in IGT and DM group than in NGT group ( P＜0.05) ; SOD, AIR3-5 and AUC were significantly lower in DM group than in IGT group ( P＜0.05) ; LDL-C, TG, 8-OHdG and MDA were significantly higher in DM group than in IGT group ( P＜0. 05). MDA and 8-OHdG were positively correlated with FPG, TG and LDL-C, and negatively correlated with FINS, HOMA-B, AUC and AIR3-5. SOD was positively correlated with FINS, HOMA-B, AUC and AIR3-5, and negatively correlated with FPG, TG and LDL-C. Multiple stepwise regression analysis showed that FPG and LDL-C were the independent factors of plasma 8 OHdG and SOD, while 8-OHdG and SOD were the independent factors of AIR3-5. Conclusion Patients with type 2 diabetes have obvious glycometabolic disorder, lipoidosis and oxidative stress. Oxidative stress takes a significant effect on the first phase of pancreatic β cell insulin secretion, which may contribute to the pathogenesis of type 2 diabetes.关键词
糖尿病,2型/氧化性应激/糖脂毒性/胰岛素分泌细胞Key words
diabetes mellitus, type 2 / oxidative stress / glucolipotoxicity/ insulin-secreting cells分类
医药卫生引用本文复制引用
李永玲,邓华聪,糜公仆,秦登优,刘强,艾艳琴..2型糖尿病患者血糖、血脂、氧化应激与β细胞功能的相关性研究[J].解放军医学杂志,2011,36(6):636-638,641,4.基金项目
国家自然科学基金(81070639、30771038、30370670) （81070639、30771038、30370670）
教育部重点项目(KJ050314),教育部博士点专项科研基金(20050631009) （KJ050314）
教育部第二批"春晖计划"资助项目 （）
