华西口腔医学杂志2011，Vol.29Issue(3)：233-236,4.DOI:10.3969/j.issn.1000-1182.2011.03.003
阿仑膦酸钠对骨质疏松种植体骨结合影响的力学研究
Effect of Alendronate sodium on torque-out testing on implant-bone interfaces in estrogen-deficient rabbits with alendronate systemic administration
摘要
Abstract
Objective To investigate the influence of systemic application of Alendronate sodium, a bone resorption inhibitor, on the osseointegration of implant-bone interface in estrogen-deficient rabbits through mechanical assessment. Methods 27 five-month-old Japanese white female rabbits were randomly divided into three groups (9rabbits each group). An ovariectomy group (OVX), an ovariectomy and Alendronate sodium group (ALN) and a shamed-operated group (S). 12 weeks after operation, implants were installed into bilateral distal femurs and proximal tibias in each group. Alendronate sodium was administrated by intraperitoneal injection in ALN group; meanwhile equivalent of normal saline was administrated by intraperitoneal injection in OVX group and S group. Bone mineral density was measured right after the implant operation and also in 4, 8, 12 weeks. Torque-out values were measured in 4, 8, 12 weeks after animal sacrifice. Results Bone mineral density of tibias in ALN group was closed to S group and was significantly different from OVX group(P＜0.05) after 8 weeks. While after 12 weeks, the bone mineral density of tibias and femurs in ALN group was both closed to S group and was significantly different from OVX group (P＜0.05).The torque-out values of tibias in ALN group were closed to S group and were significantly different from OVX group (P＜0.05) after 8 weeks. After 12 weeks, the torque-out values of tibias and femurs in ALN group were both closed to S group and were significantly different from OVX group (P＜0.05). Conclusion Systemic application of Alendronate sodium in osteoporosis rabbits can improve the bone-implant osseointegration significantly.关键词
骨性结合/阿仑膦酸钠/种植体/旋出力矩Key words
osseointegration/ Aiendronate sodium/ implant/ torque-out testing分类
医药卫生引用本文复制引用
李春艳,周延民,王林,李艳秋,付丽,宫琳..阿仑膦酸钠对骨质疏松种植体骨结合影响的力学研究[J].华西口腔医学杂志,2011,29(3):233-236,4.基金项目
教育部留学归国人员科研启动基金资助项目(教外司留2005383号) （教外司留2005383号）
