波谱学杂志2011，Vol.28Issue(2)：290-298,9.
A3G蛋白结构与功能NMR研究的最新进展
Progress in NMR-Based Studies on the Structure and Function of A3G
摘要
Abstract
The human A3G (apolipoprotein B messenger-RNA editing enzyme, catalytic polypeptide-like 3G) protein belongs to a family of polynucleotide cytidine deaminases,which is a human intrinsic immune protein with anti-viral activity. During the process of HIV virions replication, A3G is effectively incorporated into budding HIV-1 virions,catalyze C→U conversions, and then block viral replication, resulting in viral infectivity. In recent years, much attention has been paid on the structure and the process of deamination of A3G by NMR or X-ray, and significant research progress has been made,which might provide new ideal for further research. In this paper, we summarized these works in order to provide new reference for the prevention and treatment of AID＇s and hepatitis B virus and the relative new drug design.关键词
A3G/HIV/NMR/X射线衍射Key words
A3G/ HIV/ NMR, X-ray diffraction分类
数理科学引用本文复制引用
代媛媛,蓝文贤,常城..A3G蛋白结构与功能NMR研究的最新进展[J].波谱学杂志,2011,28(2):290-298,9.基金项目
国家重点基础研究发展计划资助项目(2009CB918601) （2009CB918601）
国家自然科学青年基金资助项目(20905074). （20905074）
