摘要
Abstract
Objective:To survey and analyze the content and the possible risk factors of IL-4, IL-13, IFN-γ, TGF-β in cord blood of new arrivals.Methods:The cord serum of 72 full-month, normal born, healthy new arrivals in qingdao were analyzed using ELISA for the content of IL-4,IL-13,IFN-γ,TGF-β.The allergic diseases of parents and the occurence of atopic diseases of infants within 6 months were also recorded.Results:The content of IL-4 and IL-13 in cord serum in the group of allergic families was significantly higher than the control group (P＜0.01, P＜0.05),while the content of TGF-β in cord serum in the group of allergic families was significantly lower than the control group (P＜0.01 ,P＜0.05).The overall incidence rate of eczema was 41.67 ％ in 30 follow-up infant; Food arlergy overall incidence of diarrhea was 9.72 ％ in 7 follow-up infant;Overall incidence of wheezing was 11.11％ the incidence of Atopic diseases, was 25％ in the control group,8 eases of eczema, 1 cases of food allergy diarrhea, 1 eases of wheezing; the incidence of Atopic diseases, was 54.17％in One parent quality of infant atopic group, 10 cases of eczema, 3 cases of food allergy diarrhea, 3 eases of wheezing ;the incidence of Atopic diseases, was 87.5％in Both parents quality of infant atopic group, 12 cases of eczema, 3 cases of food allergy diarrhea, 4 cases of wheezing.And the occurence of atopic diseases of infants within 6 months was significantly higher than the control group (P＜0.05).Conclusion:The content of in cord serum of new arivals possibly have clinical significance in predicting eczema and other allergic diseases.关键词
脐血/细胞因子/特应质Key words
cord serum/cytokines/atopy分类
医药卫生
