首页|期刊导航|中华医学杂志（英文版）|Clinicopathologic and prognostic implications of progranulin in breast carcinoma
中华医学杂志（英文版）2011，Vol.124Issue(13)：2045-2050,6.DOI:10.3760/cma.j.issn.0366-6999.2011.13.022
Clinicopathologic and prognostic implications of progranulin in breast carcinoma
Clinicopathologic and prognostic implications of progranulin in breast carcinoma
摘要
Abstract
Background Progranulin is a newly discovered 88-kDa glycoprotein originally purified from the highly tumorigenic mouse teratoma-derived cell line PC. Its expression is closely correlated with the development and metastasis of several cancers. However, no immunohistochemical evidence currently exists to correlate progranulin expression with clinicopathologic features in breast carcinoma biopsies, and the role of progranulin as a new marker of metastatic risk and prognosis in breast cancer has not yet been studied. The aim of this study was to investigate the clinicopathologic and prognostic implications of progranulin expression in breast carcinoma and its correlation with tumor angiogenesis. Methods Progranulin expression was determined immunohistochemically in 183 surgical specimens from patients with breast cancer and 20 tissue samples from breast fibroadenomas. The tumor angiogenesis-related biomarker, vascular endothelial growth factor was assayed and microvessel density was assessed by counting vascular endothelial cells in tumor tissues labeled with endoglin antibody. The relationship between progranulin expression and the clinicopathologic data were analyzed.Results Progranulin proteins were overexpressed in breast cancer. The level of progranulin expression was significantly correlated with tumor size (P=0.004), lymph node metastasis (P ＜0.001) and TNM staging (P ＜0.001). High progranulin expression was associated with higher tumor angiogenesis, reflected by increased vascular endothelial growth factor expression (P＜0.001) and higher microvessel density (P=0.002).Conclusion Progranulin may be a valuable marker for assessing the metastasis and prognosis of breast cancer, and could provide the basis for new combination regimens with antiangiogenic activity.关键词
breast carcinoma/progranulin/endoglin/angiogenesis/immunohistochemistryKey words
breast carcinoma/progranulin/endoglin/angiogenesis/immunohistochemistry引用本文复制引用
LI Li-qin,HUANG Hui-lian,PING Jin-liang,WANG Xiao-hong,ZHONG Jing,DAI Li-cheng..Clinicopathologic and prognostic implications of progranulin in breast carcinoma[J].中华医学杂志（英文版）,2011,124(13):2045-2050,6.基金项目
This research was supported by a grant from the National Natural Science Foundation of China (No.30772534). （No.30772534）
