首页|期刊导航|中华医学杂志（英文版）|Novel mutations of PRSS1 gene in patients with pancreatic cancer among Han population
中华医学杂志（英文版）2011，Vol.124Issue(13)：2065-2067,3.DOI:10.3760/cma.j.issn.0366-6999.2011.13.025
Novel mutations of PRSS1 gene in patients with pancreatic cancer among Han population
Novel mutations of PRSS1 gene in patients with pancreatic cancer among Han population
摘要
Abstract
Background A high mortality rate of pancreatic cancer becomes a bottleneck for further treatment with long-term efficacy. It is urgent to find a new mean to predict the early onset of pancreatic cancer accurately. The authors hypothesized that genetic variants of cationic trypsinogen (PRSS1) gene could affect trypsin expression/function and result in abnormal activation of protease activated receptor-2 (PAR-2), then lead to pancreatic cancer. The aim of this study was to elaborate some novel mutations of PRSS1 gene in the patients with pancreatic cancer.Methods Totally 156 patients with pancreatic cancer and 220 unrelated individuals as controls were enrolled in this study. The mutations of PRSS1 gene were analyzed by direct sequencing. K-ras Mutation Detection Kit was used to find the general k-ras gene disorder in the pancreatic cancer tissue. Then the clinical data were collected and analyzed simultaneously.Results There were two patients who carried novel mutations which was IVS 3 +157 G＞C of PRSS1 gene in peripheral blood specimens and pancreatic cancer tissue. What's more, it was surprising to find a novel complicated mutation of exon 3 in PRSS1 gene (c.409 A＞G and c.416 C＞T) in another young patient. The complicated mutation made No. 135 and No.137 amino acid transfer from Thr to Ala and Thr to Met respectively. No any mutation was found in the normal controls while no mutations of k-ras gene were detected in the three patients.Conclusion Mutations of PRSS1 gene may be an important factor of pancreatic cancer.关键词
pancreatic cancer/PRSS1 gene/mutationKey words
pancreatic cancer/PRSS1 gene/mutation引用本文复制引用
ZENG Kai,LIU Qi-cai,LIN Jian-hua,LIN Xin-hua,ZHUANG Ze-hao,GAO Feng ,OU Qi-shui..Novel mutations of PRSS1 gene in patients with pancreatic cancer among Han population[J].中华医学杂志（英文版）,2011,124(13):2065-2067,3.基金项目
This study was supported by grants from the Project Foundation of Fujian Provincial Education (No.JA10143),National High Technology Investigation Project Foundation of China (No.2008AA02Z433),National Natural Science Foundation of China (No.20975021,No.20805006)and the Major Program Foundation of Fujian Medical University (No.09ZD013). （No.JA10143）
