华西口腔医学杂志2011，Vol.29Issue(3)：299-301,305,4.DOI:10.3969/j.issn.1000-1182.2011.03.020
细胞周期素D1在口腔鳞状细胞癌组织中的表达及意义
Expression and its significance of Cyclin D1 in oral squamous cell carcinoma
摘要
Abstract
Objective To investigate the expression and significance of Cyclin D1 in oral squamous cell carcinoma (OSCC).Methods A immunohistochemistry method, Envosion, was employed to test the manifesting levels of Cyclin D1 in pathological slices of 50 OSCC cases and 10 normal cases, and the results was treated with statistical analysis.Results In 50 OSCC cases, Cyclin D1 mainly manifested in karyon, and a little in cytoplasm.The positive manifesting rates of Cyclin D1 in the samples was 80.0％, which was significantly higher than the manifesting rates of 20.0％ in normal oral mucous membrane(P＜0.01).The manifestation of Cyclin D1 was correlated with the different pathological grades, clinical phases and lymph node metastasis (P＜0.05).Conclusion The abnormal manifestation of Cyclin D1 is closely related with the occurrence and development of OSCC.Therefore, it can be used as subsidiary index for OSCC treatment and prognosis.关键词
口腔鳞状细胞癌/细胞周期素D1/免疫组织化学Key words
oral squamous cell carcinoma/ Cyclin D1/ immunohistochemistry分类
医药卫生引用本文复制引用
邢劲松,史培荣,陈显久,何东宁,李丽华,南欣荣..细胞周期素D1在口腔鳞状细胞癌组织中的表达及意义[J].华西口腔医学杂志,2011,29(3):299-301,305,4.基金项目
山西省科技工业攻关基金资助项目 (20090322028-1) （20090322028-1）
