广东药学院学报2011，Vol.27Issue(3)：224-226,3.DOI:10.3969/j.issn.1006-8783.2011.03.002
耳用司帕沙星脂质体原位凝胶的制备及体外释药的研究
Study on the preparation and drug release in vitro of sparfioxacin in-situ gel for ear
谢志勇1
作者信息
- 1. 湖北省妇女儿童医院药学部,湖北武汉430070
- 折叠
摘要
Abstract
Objective To prepare liposomal in-situ gel (ISG) for ear with sparfloxacin (SF) as the modeldrug,and investigate the drug release in vitro. Methods SF liposomes (SFL) were prepared by the film dispersion method. Poloxamer 407 was used as themosensitive material for the SFL-ISG. A membraneless model was used to study in vitro release of the drug and compared with that of ISG containing SF only( SFISG). Result SFL in SFL-ISG was uniformly distributed with mean size of(836.8 + 54.5) nm. The properties of the drug release in vitro and gel corrosion were in consistence with zero-order kinetics with the equation of y = 3. 0870x - 5. 2581 ( r = 0.997 8 ) and y = 0. 2299x + 1. 6892 ( r = 0. 997 3 ), respectively.Conclusion SFL-ISG can be prepared easily with suitable gelation temperature, and it may delay the drug release, which is valuable to study further.关键词
司帕沙星/脂质体/原位凝胶/体外释药Key words
sparfloxacin/ liposomes/ in-situ gel/ in vitro release of the drug分类
医药卫生引用本文复制引用
谢志勇..耳用司帕沙星脂质体原位凝胶的制备及体外释药的研究[J].广东药学院学报,2011,27(3):224-226,3.
