摘要
Abstract
Objective To study analgesic effect of sufentanil at different doses on infant during postoperation, and to explore the most suitable dose. Methods 45 cases of patients at the age between 2 to 36 months undergoing selective surgery of exploratory laparotomy with ASA Ⅰ ～ Ⅱ were divided into three groups randomly( group Ⅰ 、 Ⅱ、 Ⅲ ) , and then accepted the same anesthesia. All patients began to use analgesia pump at 30min before the end of operation. The Analgesia pump contains sufentanil and saline; the doses of sufentanil are respectively 1 μg/kg for group Ⅰ ,2 μg/kg for group Ⅱ , 3 μg/kg for group Ⅲ. Then each one was diluted to 100ml with saline water. Background infusion rate was set at 2ml/h with each press leading to quick charge of 0.5 ml, and the locking time is 15min. Analgesia and sedation scores were assessed at 4、8、16、24、48h respectively in postoperation,and the incidence of adverse reaction including respiratory inhibition, nausea, vomiting, itch of skinitchy skin etc were recorded.Results Three groups of patients have no significant difference in age, sex, weight or time of anesthesia and operation, and they all received 48 hours postoperative analgesia. The frequency of effective press in group Ⅰ is much higher than that in other groups ( P ＜ 0. 05 ). Analgesia score of each time point in group Ⅰ was significantly higher than that in group Ⅱ, Ⅲ ( P ＜ 0. 05 ); analgesia score between group Ⅱ and Ⅲ shows no significant difference ( P ＞ 0. 05 ). Sedation score of each time point in group Ⅰ was significantly higher than that in group Ⅱ , Ⅲ ( P ＜ 0. 05 ); sedation score between group Ⅱ and Ⅲ shows no significant difference (P ＞0. 05), during the whole process, three patients in group Ⅲ suffered from respiratory inhibition, with none in other two groups. All patients did not have urine retention and itchy skin during analgesia. Conclusion Continuous infusion of sufentanil 0. 04μ g/( kg · h) through vein for pediatric postoperative analgesia has satisfactory effect, which is a feasible pediatric postoperative analgesia regimen.关键词
舒芬太尼/婴幼儿/术后镇痛Key words
sufentanil/ infant/ postoperative analgesia分类
医药卫生
