中国脑血管病杂志2011，Vol.8Issue(5)：235-238,4.DOI:10.3969/j.issn.1672-5921.2011.05.003
帕罗西汀对卒中后早期抑郁的疗效及血清白细胞介素类的影响
Therapeutic effect of paroxetine on patients with early poststroke depression and the serum interleukins
摘要
Abstract
Objective To observe the effect of paroxetine on the levels of serum interleukin-1 beta (IL-1 β) and IL-6 in patients with early poststroke depression (PSD) and the degree of improvement of the depressive symptoms.Methods Two hundred twenty-three consecutive patients with stroke within 72 hours of symptom onset were included.A total of 42 patients with early PSD whose Hamilton Depression Scale (HAMD) score ≥ 8 within 72 hours of onset were selected.They were randomly allocated into paroxetine treatment group ( n = 20) and control group ( n = 22).The patients in the treatment group were treated with paroxetine 20 mg/d at the time point of 72 hours, and the course of treatment was ≥3 months.The other treatments were the same in both groups.The serum concentrations of IL-1 β and IL-6 at 72 hours, 1 and 3 months after onset, as well as the HAMD scores at all time points were compared.Results ①There was no difference in the HAMD scores between the 2 groups at 72 hours after onset.The HAMD score in the treatment group was lower than that in the control group at the same time period 1 and 3 months after treatment.There were significant difference (P ＜0.01 ).There was no significant difference in the HAMD scores between the 2 groups 1 and 3 months after treatment.②There was no significant difference in serum IL-1β and IL-6 at 72 hours after onset in both groups of patients.The IL-1β and IL-6 in the treatment group were lower than those in the control group at the same time 1 and 3 months after treatment.There were significant difference ( P ＜ 0.01 ).IL-1 β and IL-6 reached the peaks at 1 month after treatment in both groups, and began to decrease at 3 months, but the control group was still higher than the level at 72 hours ( P ＜ 0.01 ), and the treatment group was decreased to the level at 72 hours.Conclusion The increased serum IL-1β and IL-6 concentrations may be ralated to the onset of patients with early PSD.Paroxetine may improve the depressive symptoms of patients by the interference of the serum IL-1 β and IL-6.关键词
卒中/抑郁/帕罗两汀/白细胞介素1β/白细胞介素6/治疗效果Key words
Stroke/ Depression/ Paroxetine/ Interleukin-1 beta/ Interleukin-6/ Treatment outcome引用本文复制引用
杨娟,赵晓晖,朱玉萍,白青科,陈娟,夏卫英,陈练军,林同顺..帕罗西汀对卒中后早期抑郁的疗效及血清白细胞介素类的影响[J].中国脑血管病杂志,2011,8(5):235-238,4.基金项目
上海市浦东新区卫生系统医学领先人才培养基金(PWRDJ2007-02) （PWRDJ2007-02）
上海市浦东新区医学重点学科培养项目(PWZXK2010A-03) （PWZXK2010A-03）
