临床口腔医学杂志2011，Vol.27Issue(6)：334-337,4.DOI:10.3969/j.issn.1003-1634.2011.06.005
涎腺腺样囊性癌中NOS和VEGF的表达与血管生成及临床病理因素的关系
Expression of VEGF and NOS in Salivary adenoid cystic carcinoma and its relation to angiogenesis and clinical pathology.
摘要
Abstract
Objective: To study the relation of protein expression of inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS) and vascular endothelial growth factor (VECF)in salivary adenoid cystic carcinoma (SACC)and its relation to clinical pathology and angiogenesis.Method: SACC tissue specimens were obtained from 32 patients undergoing operation, by using the immunohistochemisry technique, the expression of iNOS, eNOS and VEGF were studied.Microvessel density (MVD) was counted by endothelial cell immunostained by CD34 antibodies.Result: ①Positive VEGF and iNOS and eNOS immunostaining were detected in 20 (62.5 ％), 22 (68.75 ％)and 25 (78.13 ％)patients with SACC respectively ②Expression of VEGF was significantly related to that of iNOS (P ＜0.01), but not eNOS (P ＞0.05).③MVD in SACC tissue was positively correlated with the expression of VEGF and iNOS (P ＜0.01), but not eNOS (P ＞0.05).④VEGF expression was positively correlated to the pathology category (P ＜0.05) 、lymph node metastasis (P ＜0.05) 、tumor position (P ＜0.01) 、clinicopathologic stage (P ＜0.05).INOS expression was positively correlated to the pathology category (P ＜0.01)、tumor position (P ＜0.05)、clinicopathologic stage (P ＜0.05).eNOS showed no relation to above clinico-pathological fealures (P ＞0.05).Conclusion :INOS, rather than eNOS, plays a positive role in SACC development.iNOS and VEGF have a positive correlation in angiogenesis of SACC.关键词
涎腺腺样囊性癌/血管内皮生长因子/一氧化氮合酶/血管生成Key words
salivary adenoid cystic carcinoma/ vascular endothelial growth factor/ nitric oxide synthase/ angiogenesis分类
医药卫生引用本文复制引用
李晓光,于肖鹏,刘萍,王延秀..涎腺腺样囊性癌中NOS和VEGF的表达与血管生成及临床病理因素的关系[J].临床口腔医学杂志,2011,27(6):334-337,4.基金项目
泰安市科技局资助项目(2007-46) （2007-46）
