中国临床心理学杂志2011，Vol.19Issue(3)：289-292,4.
5-羟色胺转运体基因启动子区CpG岛甲基化状态与精神分裂症Ⅰ型和Ⅱ型的关联
Relationship Between Methylation Status of CpG Islands within the Promoter Region of Serotonin Transporter Gene and Type Ⅰ or Type Ⅱ Schizophrenia
摘要
Abstract
Objective: To explore the relationship between methylation status of CpG islands in the promoter region of serotonin transporter gene (5-HTT) and type Ⅰ or Ⅱ schizophrenia. Methods: Methylation Specific PCR and DNA sequencing were used to detect the methylation status of CpG islands in 62 type Ⅰ schizophrenia patients, 38 type Ⅱ schizophrenia patients and 50 health subjects. Results: The methylation rates of CpG islands within the promoter region of 5-HTT of the three groups are 52％ (32/62), 47％ (18/38) and 50％ (25/50), respectively. The methylation rates of loci in CpG islands within the promoter region of 5-HTT in type Ⅰ schizophrenia group is significantly higher than those in type Ⅱ schizophrenia group and health subjects. Conclusion: The high methylation rate of loci in CpG islands within the promoter region of 5-HTT should be a possible factor to influence the nosogenesis of type Ⅰ schizophrenia.关键词
精神分裂症/甲基化/5-羟色胺转运体(5-HTT)Key words
Schizophrenia/ Methylation/ Serotonin transporter分类
医药卫生引用本文复制引用
张海生,王伟,余道军,张顺泉,谢健..5-羟色胺转运体基因启动子区CpG岛甲基化状态与精神分裂症Ⅰ型和Ⅱ型的关联[J].中国临床心理学杂志,2011,19(3):289-292,4.基金项目
杭州市科技计划项目(20090833B06) （20090833B06）
