中国普通外科杂志2011，Vol.20Issue(6)：599-604,6.
精氨酸加压素对脓毒症大鼠动脉压力反射的
Effect of arginine vasopressin on arterial baroreflex in septic rats
摘要
Abstract
Objective To investigate the effects of central and peripheral injection of arginine vasopressin (AVP) on arterial baroreflex (ABR) function in septic rats.Methods Rat sepsis model was induced by cecal ligation and puncture (CLP).(1) The ABR function and AVP expressions in supraoptic and paraventricular nucleus of the 2 grous were measured at 4, 8 and 12 h after operation, respectively.The sham operated rats were used as control; (2) Sepsis rats were given AVP (50 ng ), and artificial cerebrospinal fluid of the same volume were given to control rats by intracerebroventricular injection 8 h after operation.The ABR functions of the 2 group rats were determined at 5 and 30 min after injection.(3)Sepsis rats were given AVP [2 ng/( kg · h )]and control rats were given saline of the same volume by continuous intravenous infusion 6 h after CLP.The ABR functions of the 2 group rats were determined at 5 and 30 min after infusion.Results In sepsis rats showed gradual decrease in ABR function, as well as a gradual reduction of AVP expressions in supraoptic and paraventricular nucleus.Both intracerebroventricular injection and continuous intravenous infusion with AVP significantly improved the ABB functions in sepsis rats compared with control group rats ( both P ＜ 0.05 ).Conclusions In sepsis, the reduction of AVP expression in supraoptic and paraventricular nucleus induces a decrease in ABR function, which may probably contribute to the development of sepsis.Use of exogenous AVP in the initial phase of sepsis can improve ABR function and delay the development of sepsis.关键词
脓毒症/精氨酸加压素/压力反射/大鼠Key words
Sepsis/ Arginine Vasopressin/ Arterial Baroreflex/ Rat分类
医药卫生引用本文复制引用
杨磊,柴琛,程东升,刘颖璐,乔玮,鲁彦,曹农..精氨酸加压素对脓毒症大鼠动脉压力反射的[J].中国普通外科杂志,2011,20(6):599-604,6.基金项目
国家自然科学基金资助项目(30700266) （30700266）
陕西省卫生厅资助项目(06E05) （06E05）
中央高校基本科研业务费专项资金(lzujbky-2010-146). （lzujbky-2010-146）
