摘要
Abstract
Aim: To investigate the expression of inducible nitric oxide synthase(iNOS) mRNA in human gastric cari-noma tissue, precarcinoma changes, chronic inflammation tissue and to identify the significance of iNOS expression. Methods : iNOS mRNA were detected in 35 cases chronic superficial gastritis ( CSG) , 24 cases chronic atrophic gastritis with intestinal metaplasia( CAG + IM) , 21 cases gastric mucosal atypical hyperplasia( GMAH) and 65 cases gastric carcinoma ( GC) tissue specimens using in situ hybridization. Results: There was significant difference on positive expression rate of iNOS mRNA among GC (75.4% ,49/65) ,CSG(17. 1% ,6/35) , CAG + IM(45.8% ,11/24) and GMAH (52. 4% ,11/ 21 )tissues(x2 = 31.646,P <0.001 ). The expression of iNOS mRNA in GC was associated with histological grade, invasive depth and lymph node metastasis^2 =5. 122, 5. 182, and 13. 213 ,P < 0. 05) .without size, location (x2 =1.866, and 0. 366 ,P > 0.05 ) . Conclusion: iNOS might be closely correlated with occurrence, invasion and metastasis of GC.关键词
胃癌/诱导型一氧化氮合酶/原位分子杂交法Key words
gastric carcinoma/ inducible nitric oxide synthase/in situ hybridization分类
医药卫生
