摘要
Abstract
Objective To investigate the expressions and clinical significance of matrix metalloproteinase( MMP )-1,2 and insulin-like growth factor-1( IGF-1 ) in fractures patients. Methods 38 fractures patients were divided into two groups by fractures healing: 22 patients in group A ( healed fractures ), 16 patients in group B ( non-healed fractures ). 20 subjects were in group C as normal controls. Peripheral blood samples were taken for determination of the serum levels of MMP-1,MMP-2,IGF-1 on 1 d,7 d and 30 d since fractures by ELISA. Results The MMP-1 was as follows: serum levels of MMP-1 at 7 d not only between group A and C but also between group B and C were significant different( P ＜ 0. 01 ); serum levels of MMP-1 at 30d not only between group A and B but also between group B and C were significant different( P ＜ 0. 01 );in group A, serum level of MMP-1 at 30d was significant different than its previous time point( P ＜ 0. 01 );in group B, serum levels of MMP-1 at 7d and 30d were significant different than their previous time points separately( P ＜ 0. 05 ). The MMP-2 result was as follows: serum levels of MMP-2 at 7d not only between group A and C but also between group B and C were significant different( P ＜ 0. 01 ); serum levels of MMP-2 at 30 d were significant different than each other group( P ＜ 0. 01 ); in group A, serum levels of MMP-2 at 7d and 30d were significant different than their previous time points separately( P ＜ 0. 01, P ＜ 0. 05 ); in group B, serum level of MMP-2 at 7d was significant different than its previous time point( P ＜0. 01 ). The IGF-1 result was as follows: serum levels of IGF-1 at 7 d not only between group A and C but also between group B and C were significant different ( P ＜ 0. 01 ); serum levels of IGF-1 at 30d were significant different than each other group( P ＜ 0. 01 ); in group A,serum level of IGF-1 at 7d was significant different than its previous time point( P ＜ 0. 01 );in group B, serum levels of IGF-1 at 7d and 30d were significant different than their previous time points separately( P ＜ 0. 05, P ＜ 0. 01 ).Conclusions Detection of serum levels of MMP-1; MMP-2;IGF-1 at 30d is of great value in prognosis prediction in fractures.关键词
基质金属蛋白酶-1/基质金属蛋白酶-2/类胰岛素样生长因子-1/酶联免疫吸附法/骨折愈合Key words
MMP-1/ MMP-2/ IGF-1/ ELISA/ fractures healing分类
医药卫生
