中国药理学通报2011，Vol.27Issue(9)：1189-1192,4.DOI:10.3969/j.issn.1001-1978.2011.09.002
肝纤维化中星状细胞促血管生成分子机制的研究
Molecular basis of hepatic stellate cell-driven angiogenesis implicated in liver fibrosis
摘要
Abstract
Hepatic fibrogenesis coexists with pathological angiogenesis and vascular remodeling, constituting barriers to fibrosis regression and recovery. Angiogenesis has been emerging as a potential therapeutic target for liver fibrosis, and several antiangiogenic agents have indeed exhibited antifibrotic profiles in preclinical studies. Hepatic stellate cells as liver specific pericytes modulate multiple stages of liver pathological angiogenesis by expressing a number of proangiogenic cytokines including vascular endothelial growth factor, platelet-derived growth factor, leptin and angiopoietin-1. This review highlights the molecular mechanisms of fibrotic angiogenesis driven by stellate cells in the hope of providing new insight into hepatic fibrogenesis beneficial to the discovery of novel pharmacological targets.关键词
肝纤维化/血管生成/肝星状细胞/血管内皮生长因子/血小板衍生生长因子/瘦素/血管生成素-1Key words
hepatic fibrosis/ angiogenesis/ hepatic stellate cell/ vascular endothelial growth factor/ platelet-derived growth factor/ leptin/ angiopoietin-1分类
医药卫生引用本文复制引用
张峰,魏东华,孔德松,张晓平,陆茵,王爱云,陈文星,郑仕中..肝纤维化中星状细胞促血管生成分子机制的研究[J].中国药理学通报,2011,27(9):1189-1192,4.基金项目
国家自然科学基金资助项目(No 30873424) （No 30873424）
江苏省自然科学基金资助项目(No BK200856) （No BK200856）
江苏省针灸学重点实验室开放课题资助项目(No KJA200801) （No KJA200801）
教育部博士点博导基金资助项目(No 20103237110010) （No 20103237110010）
江苏省六大人才基金资助项目(No 2009-B-010) （No 2009-B-010）
江苏高校优势学科建设工程资助项目 （）
