中国药理学通报2011，Vol.27Issue(9)：1231-1235,5.DOI:10.3969/j.issn.1001-1978.2011.09.012
周边γ-氨基丁酸通过GABAB受体调控骶髓后联合核神经元谷氨酸能突触
Ambient GABA modulates glutamatergic synapse in sacral dorsal commissural nucleus by presynaptic GABAB receptors
摘要
Abstract
Aim To investigate the role of ambient γ-aminobutyric acid ( CABA ) on glutamatergic synapse via CABAB receptors in sacral dorsal commissural nucleus ( SDCN ). Method Using whole-cell voltageclamp recordings on acute spinal cord slice, effect of blockade of CABAB receptors on glutamatergic synaptic transmission was studied. Results Blockade of GABAB receptors by a selective antagonist CGP52432 increased evoked excitatory postsynaptic currents ( eEPSCs ) , decreased paired-pulse ration ( PPR ). switched " presynaptically" silent synapse to active one, indicating a presynaptic GABAB receptor-mediated modulation by ambient GABA. Conclusions Ambient GABA modulates glutamate release by GABAB receptors on presynaptic glutamatergic terminals to SDCN neurons;this action may contribute to nociception transmission at spinal cord level.关键词
骶髓后联合核/γ-氨基丁酸/GABAB受体/谷氨酸/全细胞记录/脊髓/大鼠Key words
sacral dorsal commissural nucleus/ GABA/ CABAB receptors/ glutamic acid/ whole-cell recordings / spinal cord / rat分类
医药卫生引用本文复制引用
马红雨,林凯,罗丹,吕建晓,杨鲲..周边γ-氨基丁酸通过GABAB受体调控骶髓后联合核神经元谷氨酸能突触[J].中国药理学通报,2011,27(9):1231-1235,5.基金项目
国家自然科学基金资助项目(No 30000052) （No 30000052）
