中国药理学通报2011，Vol.27Issue(9)：1249-1253,5.DOI:10.3969/j.issn.1001-1978.2011.09.016
度洛西汀对大鼠胸主动脉环舒张功能的影响
Effect of duloxetine on vasodilatation of rat isolated thoracic aortas
摘要
Abstract
Aim To investigate the effect of duloxetine DLX )on vasodilatation of rat aortic rings and the mechanism. Methods The isolated thoracic aortic rings of male Wistar rats were mounted on the organ bath and tension was recorded isometrically. The effect of DLX on the rings with endothelium intact or endothelium denuded precontracted by the potassium chloride ( KCl, 30 mmol ·L-1 ) or norepinphrine( NE, 1 μmol · L-1 ), and the effect of DLX on the vessel reaction induced by various drugs were recorded with biological signal analytical system. Results DLX completely relaxed the contractions induced by KCl and NE in a concentration-dependent manner in endotheliumintact and endothelium-denuded rat aorta. The vasodilator effect of DLX was not statistically inhibited by glibenclamide ( Gli, 10 μmol · L-1 ). tetraethtylamine ( TEA. 10 mmol · L-1 ), barium chloride ( BaCl2 , 1 mmol · L-1 ).4-aminopyridine ( 4-AP,1 mmol · L-1 )and cyproheptadine( 1 μmol · L-1 ) in KCl pre-contracted thoracic aortic rings . The vasodilator effect of DLX was partially inhibited by prazosin ( I μmol · L-1 ). DLX could significantly inhibit the contraction induced by additions of NE in Ca2+-free PSS, and the contraction induced by additions of CaCl2. Conclusion DLX-induced vasodilatation is mainly related to blocking α1-adrenoceptor, and interfering intracellular calcium homeostasis by blocking Ca2+ influx and intracellular Ca2+ release.关键词
度洛西汀/钾通道/α1受体/钙通道/血管舒张/大鼠动脉Key words
duloxetine/ potassium channel/ α1-adrenoceptor/ calcium channel/ vasodilatation/ rat aorta分类
医药卫生引用本文复制引用
郭芬芬,任俊杰,王君,武冬梅,梁月琴,吕志杰..度洛西汀对大鼠胸主动脉环舒张功能的影响[J].中国药理学通报,2011,27(9):1249-1253,5.基金项目
山西省自然科学基金项目 (No 2008011076-4) （No 2008011076-4）
山西省回国留学人员科研资助项目(No 2007-42) （No 2007-42）
