中国药理学通报2011，Vol.27Issue(9)：1292-1294,3.DOI:10.3969/j.issn.1001-1978.2011.09.026
合成棕点湍蛙抗菌肽的抗菌活性评价
Antibacterial activity evaluation of palm point turbulent frog antimicrobial peptides
赵铁华 1程玉洁 1李哲1
作者信息
- 1. 河北师范大学药物研究所,河北,石家庄,050016
- 折叠
摘要
Abstract
Aim To analyze the bacteriostasis of the palm point turbulent frog antimicrobial peptide, discuss the consistency of the synthetic and the natural product, and evaluate its clinical applications. Methods The MBC of the antimicrobial peptides and the MBC when it was combined with gentamycin, penicillin and streptomycin to S. aureus and E. coli in vitro were determined. Results The antimicrobial peptide showed certain bactericidal effects both on S. aureus and E. coli. The MBC was 200 mg · L-1 and 100 mg · L-1respectively, which was lower than that in the natural product extracted by biochemistry method. The bactericidal effects were enhanced by joint utilization with gentamycin, penicillin and streptomycin, especially with penicillin, when the MBC of penicillin/antimicrobial peptides was 0. 625 mg · L-1/25 mg · L-1. Conclusion Antibacterial peptides possibly help to improve the drug resistance of pathogen to traditional antibiotics.关键词
抗菌肽/棕点湍蛙/合成/金黄色葡萄球菌/大肠埃希菌/最小杀菌浓度Key words
antimicrobial peptides/ palm point turbulent frog/ synthesis/ S. aureus/ E. coli/ MBC分类
医药卫生引用本文复制引用
赵铁华,程玉洁,李哲..合成棕点湍蛙抗菌肽的抗菌活性评价[J].中国药理学通报,2011,27(9):1292-1294,3.
