摘要
Abstract
Aim To investigate the level of matrix metalloproteinase-3 of peripheral blood from acute coronary syndrome patients and to analyize the relationship among matrix metalloproteinase-3, myocardium enzymes, troponins,blood-fat, and severity of coronary artery disease.Methods To contrast matrix metalloproteinase-3 of peripheral blood from 77 acute coronary syndrome patients of our hospital and normal controls, and to analyze relationship among matrix metalloproteinase-3 of peripheral blood, myocardium enzymes, troponins, blood-fat, and severity of coronary artery disease.Serum level of matrix metalloproteinase-3 was measured by enzyme linked immunosorbent assay.Results Compared with stable angina pectoris group and control group, the level of matrix metalloproteinase-3 in acute myocardial infarction group had statistically significant difference (P ＜ 0.01 ).Compared with stable angina pectoris group and control group, statistical significance of difference was seen in unstable angina pectoris group ( P ＜ 0.01 ).There is no significant difference between acute myocardial infarction and unstable angina pectoris group, as well as stable angina pectoris and control group.Matrix metalloproeinase-3 and troponin Ⅰ, creatine kinase, MB isoenzymes of creatine kinase had positive correlation, There were no correlation between matrix metalloproteinase-3, triglyeride, low density lipoprotein cholesterol.Matrix metalloproteinase-3 level and coronary artery radiography pathological change severity were performed by Pearson correlation: there were no correlation ( r= 0.293; P = 0.053 ).There were significant difference of matrix metalloproteinase-3 in 10 patients with acute myocardial infarction before and after percutem coronary artery interventional therapy ( P ＜ 0.01 ).Conclusion The level of matrix metalloproteinase-3 of peripheral blood in patients with acute coronary syndrome was increased.The level of matrix metalloproteinase-3 and coronary artery radiography severity had no correlation.Matrix metalloproteinase-3 and troponin Ⅰ, creatine kinase, MB isoenzymes of creatine kinase had positive correlation in patients with acute myocardial infarction.关键词
急性冠状动脉综合征/基质金属蛋白酶/动脉粥样硬化斑块Key words
Acute Coronary Syndrome/ Matrix Metalloproteinase/ Atherosclerotic Plaque分类
医药卫生
