中国动脉硬化杂志2011，Vol.19Issue(5)：439-445,7.
多聚赖氨酸结合脂蛋白(a)检测方法的初步确立及其对急性心肌梗死的实验诊断价值
Tentatively Establishing the Method of Detecting Lipoprotein(a) of Combining to Polyphosphate Lysine and the Laboratory Diagnostic Value of the Method in Acute Myocardial Infarction
张金红 1刘爱兵 1韩润林 2刘晓军 3程志英3
作者信息
- 1. 中国人民解放军武警总医院医学实验中心,北京市,100039
- 2. 内蒙古农业大学脂蛋白免疫学研究中心,内蒙古呼和浩特市,010018
- 3. 中国人民解放军武警总医院药房,北京市,100039
- 折叠
摘要
Abstract
Aim To establish the method of detecting functional lipoprotein (a) [Lp (a)], and evaluate it, then compare its effect with creatine kinase isozyme at the diagnosis and detection of the acute myocardial infarction. Methods The level of lipoprotein(a) and lipoprotein(a) combining to polyphosphate lysine at preoperative and postoperative 4 h, 8 h, 12 h, 24 h, 48 h and 72 h, 4 ～9 days and 10 ～ 12 days points were detected respectively in acute myocardial infarction and unstable angina patients by enzyme-linked immunosorbent assay and immune turbidimetric assay. Results The change of lipoprotein(a) level was lower(P ＞ 0. 05 ); However, the change of lipoprotein(a) combining to polyphosphate lysine was larger in acute myocardial infarction ( P ＜ 0. 05 ); The precision and accuracy of the method is better ( ＞ 90％ ); The diagnostic value was more superior than creatine kinase isozyme. Conclusion The level of lipoprotein(a) detected by traditional methods fail to associate with the cardiovascular disease; The method that detecting the level of lipoprotein (a) combining to polyphosphate lysine can diagnose and nonitor cardiovascular disease, and the method can be used to research the pathological mechanism of lipoprotein(a).关键词
脂蛋白(a)/多聚赖氨酸/急性心肌梗死Key words
Lipoprotein(a)/ Polyphosphate Lysine/ Acute Myocardial Infarction分类
医药卫生引用本文复制引用
张金红,刘爱兵,韩润林,刘晓军,程志英..多聚赖氨酸结合脂蛋白(a)检测方法的初步确立及其对急性心肌梗死的实验诊断价值[J].中国动脉硬化杂志,2011,19(5):439-445,7.
