中国动脉硬化杂志2011，Vol.19Issue(6)：539-542,4.
氧化应激和肺动脉高压血管重构
Oxidative Stress and Vascular Remodeling in Pulmonary Hypertension
刘斌1
作者信息
- 1. 中南大学药学院药理学系,湖南省长沙市,410078
- 折叠
摘要
Abstract
Oxidative stress is involved in vascular remodeling and development of pulmonary hypertension (PH)through multiple pathways such as promoting pulmonary arterial vascular smooth muscle cells proliferation, enhancing endothelial dysfunction and accelerating extracellular matrix deposition. Recent studies have indicated that antioxidant therapy can effectively inhibit pulmonary vascular remodeling and the progress of PH, which provides further evidence that oxidative stress plays an important role in pulmonary vascular remodeling as well as in PH. It is the basis of antioxidant therapy and the research direction for PH to clarify the redox signaling pathway under pathological conditions and to seek specific drugs for antioxidant therapy.关键词
氧化应激/血管重构/肺动脉高压/平滑肌细胞/内皮损伤Key words
Oxidative Stress/ Vascular Remodeling/ Pulmonary Hypertension/ Smooth Muscle Cells/ Endothelial Dysfunction分类
医药卫生引用本文复制引用
刘斌..氧化应激和肺动脉高压血管重构[J].中国动脉硬化杂志,2011,19(6):539-542,4.
