生物信息学2011，Vol.9Issue(2)：176-180,5.DOI:10.3969/j.issn.1672-5565.2011.02.019
小鼠DEAF1调控基因的生物信息学分析
Bioinformatic Analysis of Mouse Genes Controlled by DEAF1
摘要
Abstract
DEAF1 is a transcription factor, it controlled ahout 600 genes expression m mouse pancreatic lymph nodes.Searching promoter regions ( +/ - 2kb of transcript start site) for genes on the list with Clover program, it is found that nearly half of the genes controlled by DEAF1 contain consensus sequence binding by DEAF1. Tissue specific expression profiling is analyses with TiGER and MGI database. Most of the genes on the list are expressed in multiple tissues, some of them expressed in one specific tissue or few specific tissues. There are 228 genes expressed in pancreas, 131 genes expressed in both pancreas and lymph nodes. Most of the genes expressed both in pancreas and lymph nodes contain TTTC( C/G) G motif. The above results may play a very important role in the future research for mechanisms of peripheral tissue antigens expression regulation and maintenance of peripheral tolerance.关键词
小鼠/DEAF1/基因表达调控/生物信息学Key words
Mouse/ DEAF1 / gene expression regulation/ bioinformatics分类
生物科学引用本文复制引用
盛德乔..小鼠DEAF1调控基因的生物信息学分析[J].生物信息学,2011,9(2):176-180,5.基金项目
湖北省教育厅科学技术研究项目 D20101205 宜昌市科学技术研究与开发项目(A01301-01). （A01301-01）
