中山大学学报(自然科学版)2011，Vol.50Issue(3)：98-101,4.
祛痰止咳颗粒指纹图谱研究
HPLC Fingerprint of Qutanzhike Granule
摘要
Abstract
HPLC fingerprint of Qutanzhike Granule was established with Elite Hypersil BDS column (4.6 mm ×250 mm, 5 μm), methanol (A) and 0.15％ acetic acid (B) as mobile phase.The elution profile was: 0 ～95 min 15％ to 75％ A in B (linear gradient).The column temperature was set at 25 ℃ and the flow rate was 1.0 mL/min.The detective wavelength was at 260 nm.19 common peaks were selected as the fingerprint peaks from 12 batches of the production.In the established fingerprint,10 flavonoids were identified by the HPLC-ESI/MS/MS based on MS spetra and standard reference.The method can be used for quality control of Qutanzhike Granule with great precision, accuracy and good reproducibility.关键词
祛痰止咳颗粒/高效液相色谱法/指纹图谱Key words
Qutanzhike Granule/ HPLC/ fingerprint分类
医药卫生引用本文复制引用
郑文燕,王晓东,彭维,沈艺,苏薇薇..祛痰止咳颗粒指纹图谱研究[J].中山大学学报(自然科学版),2011,50(3):98-101,4.基金项目
广东省科技计划资助项目(2010B050100013) （2010B050100013）
