材料工程Issue(6)：58-62,5.
等离子体处理乙丙交酯共聚物表面固定胶原的研究
Investigation of Plasma Treatment and Collagen Immobilization on the Surface of Poly(lactid-glycolide acid)
摘要
Abstract
For collagen is a major component of the extracellular matrix, when the surface of poly(lactid-glycolide acid) (PLGA) is grafted with collagen, cytocompatibility of PLGA will be improved. Plasma treatment is selected to immobilize collagen on the surface of PLGA. Optimum power and treating time of plasma are determined by contact angle test. The results indicate they are 60W and 5min, respectively. XPS analysis reveals that carboxy groups on collagen are reacted with actived hydroxyl groups on the surface of plasma treated PLGA to form ester groups. Then collagen is immobilized on PLGA. Cytocompatibility evaluation of collagen immobilized PLGA(COL-PLGA) was carried out by seeding 3T3 cells on the surface of COL-PLGA. Quanlitative and quantitative analysis proved that cell adhesion and proliferation are improved after collagen grafting. Quantitative result is obtained by MTT assay in cell living period.关键词
PLGA/等离子体/胶原Key words
PLGA / plasma/ collagen分类
化学化工引用本文复制引用
崔媛,段潜,李艳辉..等离子体处理乙丙交酯共聚物表面固定胶原的研究[J].材料工程,2011,(6):58-62,5.基金项目
国家自然科学基金资助项目(50903009) （50903009）
吉林省科技发展计划项目(20100115) （20100115）
