高校化学工程学报2011，Vol.25Issue(3)：459-464,6.
捷安肽素固定化细胞分批发酵过程动力学分析
Batch Fermentation Kinetic Analysis of Jiean-Peptide Production by Immobilized Cells
摘要
Abstract
Using Sigmoid model the unstructured kinetics of Jiean-peptide (JAA) batch fermentation process in 5 L bioreactor by immobilized bacillus subtilis cells was investigated, and the specific rates of cell growth and JAA formation, glucose consumption and total nitrogen consumption were analyzed and calculated. The results show that the Sigmoid model can match well with the JAA batch fermentation process in 5 L bioreactor by immobilized bacillus subtilis cells, and the squares of correlation corresponding to Sigmoid model exceed 0.971. The maximum specific rates of cell growth, JAA formation, glucose consumption and total nitrogen consumption are 0.411, 0.001, 0.771 and 0.043 h-1, respectively. The maximum yields coefficient of cell and JAA from glucose is 2.1 and 0.029 g·g-1, respectively, and the maximum yields coefficient of cell and JAA from total nitrogen is 51 and 3.4 g.g-1, respectively. The relation between the cell growth and JAA formation is a relation combining growth-associated and nongraoth-associated processes.关键词
捷安肽素/固定化细胞/分批发酵/发酵动力学/枯草芽孢杆菌Key words
Jiean-peptide/ immobilized cells/ batch fermentation/ fermentation kinetics/ Bacillus subtilis分类
化学化工引用本文复制引用
张晓勇,钟娟,李志东,周金燕,杨杰,肖亮,谭红..捷安肽素固定化细胞分批发酵过程动力学分析[J].高校化学工程学报,2011,25(3):459-464,6.基金项目
中国科学院知识创新工程重要方向项目(KSCX2-YW-G-039-2,KSCX2-EW-G-16) （KSCX2-YW-G-039-2,KSCX2-EW-G-16）
国家科技支撑计划课题(2011BAE06B04). （2011BAE06B04）
