应用化学2011，Vol.28Issue(6)：611-623,13.DOI:10.3724/SP.J.1095.2011.00455
亲和型生物传感器在生物医学上的应用进展
Recent Advance of Affinitive Biosensors in Biomedical Applications
摘要
Abstract
Biosensors have received vigorous development and serious concern in recent years owing to the combinations with nanotechniques, flow-injection and micro-fluidics devices. Affinitive biosensor is a kind of high-tech sensing device based on the specific affinity between biological molecules, and the affinity of bioactive substance and substrate. With the advantages of high specificity, good sensitivity, high speed, low cost, on-line measuring and monitoring in complicated system, affinitive biosensors are widely used in biomedical fields, such as the detection of biomedical markers, nucleic acids, proteins, viruses, bacteria and toxins, the research of medicine actions mechanism, clinical drug screening, and etc. In this paper, the recent advance of affinitive biosensors in biomedical applications are reviewed. We also focus on a growing number of applications and progress in immunosensors and aptamer-based biosensors for tumor biomarker, nucleic acids and proteins. It covers the basic principles and biomedical and clinical applications of immunosensors and aptamer-based biosensors, and indicates the future prospects in this field.关键词
亲和型生物传感器/免疫传感器/肿瘤标记物/核酸适体传感器/生物医学应用Key words
affinity biosensor, immunosensor, tumor biomarker, aptamer-based biosensor, biomedical application分类
化学化工引用本文复制引用
刘传银,胡继明..亲和型生物传感器在生物医学上的应用进展[J].应用化学,2011,28(6):611-623,13.基金项目
湖北省教育厅优秀中青年项目(Q200760001)、十堰市科技计划及开发项目(2010nt05)资助 （Q200760001）
