应用化学2011，Vol.28Issue(6)：704-708,5.DOI:10.3724/SP.J.1095.2011.00431
琥乙红霉素在碳糊电极上的电化学测定方法
Electrochemical Determination of Erythromycin Ethylsuccinate Using a Carbon Paste Electrode
摘要
Abstract
A carbon paste electrode used as the working electrode, the electrochemical behavior of erythromycin ethylsuccinate (EEs) was investigated by cyclic voltammetry ( CV ) and differential pulse voltammetry ( DPV ) , a novel method was proposed for the determination of EEs. The results showed two irreversible- anodic peaks appeared at 0. 83 V and 0. 97 V, respectively in 0. 1 mol/L PBS buffer solution (pH =8. 0), indicating that there were two-step irreversible oxidations. Quantitative measurements by chronoamperometry(/-f) showed that the peak currents were proportional to erythromycin ethylsuccinate concentration in the range of 2. 0 ×10-7 ～ 2. 8 × 10 -6 and 2. 8× 10 -6 ～3. 1 × 10-5 mol/L, respectively, with the detection limit (S/N = 3 ) of 1.0 × 10-7 mol/L. The recovery was in the range of 95. 0％ ～98. 8％ with a RSD of 3. 4％ ( n = 3 ). The method showed a high selectivity and sensitivity, and could be used for the determination of EEs in the drugs with satisfactory result.关键词
琥乙红霉素/碳糊电极/电化学测定/计时安培法Key words
erythromycin ethylsuccinate, carbon paste electrode, electrochemical determination,chronoamperometry分类
化学化工引用本文复制引用
任艳艳,金根娣,胡效亚..琥乙红霉素在碳糊电极上的电化学测定方法[J].应用化学,2011,28(6):704-708,5.基金项目
国家自然科学基金(20875081,21075107)资助项目 （20875081,21075107）
