中国临床医学2011，Vol.18Issue(3)：338-340,3.
进展期胃癌患者术后腹腔持续温热灌注化疗联合静脉化疗的疗效观察
Postoperative Intraperitoneal Hyperthermia Chemoperfusion Combined with Intravenous Chemotherapy for Advanced Gastric Cancer Patients
张峰 1刘国平 1刘畅 1刘晓军2
作者信息
- 1. 复旦大学附属金山医院急诊科,上海,200540
- 2. 上海第二军医大学,上海,200433
- 折叠
摘要
Abstract
Objective:To evaluate the efficacy of postoperative intraperitoneal hyperthermia chemo perfusion(IHCP )combined with intravenous chemotherapy for advanced gastric cancer. Methods: A total of 135 advanced gastric cancer patients were postoperatively randomized into two groups; 67 patients in treatment group who received IHCP combined with intravenous chemotherapy for four times and 68 patients in control group who received intravenous chemotherapy only for twelve times; All patients in the two groups received the same chemo-regimen FOLFOX6 after 4 weeks of operation. Results: ① The 1-year survival rate was 95.38％in the treatment group and 93.21 ％in the control group without significant difference(P＞0. 05). The 3-year and the 5-year survival rate was 78.63 ％ and 58.47 ％ in the treatment group, but was 67.95 ％ and 41.81％ in the control group with significant difference (P＜0.05). ②Kamofsky scale(KPS) increasing rate was 59.70 ％ in treatment group versus 42.65 ％ in control group respectively(P＜0.05) ;③ The intraperitoneal recurrence rate in chemotherapy group was lower than that in control group(14.92％ vs. 30. 88％ ,P＜0.05) ,and the distant metastasis rate without significant difference(32.84 ％ vs. 35.29 ％, P＞0. 05) ;④ Most of side effects and complication are gastrointestinal reaction and bone marrow suppression, but no one effect the normal cure. Conclusions: Intraperitoneal hyperthermia chemoperfusion (IHCP)combined with intravenous chemotherapy can prolong survival and reduce gastrointestinal side-effect which provides an effective treatment option for advanced gastric cancer patients.关键词
进展期胃癌/腹腔持续温热灌注化疗/静脉化疗Key words
Advanced gastric cancer/ Intraperitoneal hyperthermia chemoperfusion(IHCP)/ Intravenous chemotherapy分类
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张峰,刘国平,刘畅,刘晓军..进展期胃癌患者术后腹腔持续温热灌注化疗联合静脉化疗的疗效观察[J].中国临床医学,2011,18(3):338-340,3.
