烟草科技Issue(5)：43-47,5.
袋装口含型无烟气烟草制品烟碱体外释放分析
In vitro Test of Nicotine Release from Bagged Oral Smokeless Tobacco Products
摘要
Abstract
A device for simulating nicotine release from oral smokeless tobacco product in human mouth was developed, which consisted of a container for solvent, a constant flow pump, a constant temperature trough, a pre-heating coil, a thermostatic tube, a thermostatic cell, and a liquid collector.The thermostatic cell acted as a buccal cavity to ensure nicotine to be released in the cell under a constant temperature of 37 ℃.The device was convenient in operation and good in stability and could effectively simulate nicotine release behavior of oral smokeless tobacco products and distinguish the difference of nicotine release between different products.The novel technique is suitable for quality evaluation, and nicotine level control of oral smokeless tobacco products as well as the assessment of bioavailability of nicotine.关键词
口含型无烟气烟草制品/烟碱/体外释放/释放装置Key words
Oral smokeless tobacco product/ Nicotine/ In vitro release/ Release device分类
轻工纺织引用本文复制引用
张杰,李鹏,彭书海,宗永立,孙世豪,钱发成,谢剑平..袋装口含型无烟气烟草制品烟碱体外释放分析[J].烟草科技,2011,(5):43-47,5.基金项目
国家烟草专卖局资助重点科研项目"无烟气烟草制品研制袋装口含型无烟气烟草制品"(412008AA005D). （412008AA005D）
