同位素2011，Vol.24Issue(2)：77-82,6.
NGR短肽的188Re标记及其在荷瘤裸鼠体内的生物分布和SPECT显像
Labeling of NGR Peptide With 188Re and Its Biodistribution and SPECT Imaging in Tumor-bearing Nude Mice
摘要
Abstract
To evaluate its radiochemical characteristics, biodistribution and imaging for nude mice bearing HepG2, 188Re-NGR was prepared directly with 2-mercapto-ethanol as reductant and sodium gluconate as middle ligand. The labeling yield of 188 Re-NGR was more than 85％, and the radiochemical purity (RCP) was more than 90％. In vivo, 188Re-NGR can specifically bind with tumor. The tumor uptake was (2.84±0.51)％ID/g at 1 h after injection, the uptake was(4. 62±0. 71)％ID/g at 12 h and remains (2.01±0.38)％ID/g for 24 h, the contrl group was (1.43±0.61)％ID/g. The ratio of tumor to muscle was 4.76 at 12 h. The xenografted tumor became visible at 1 h and was the most clearly at 12 h. The results showed that NGR had the function of good targeting.关键词
NGR/188Re/标记/SPECTKey words
NGR/ 188Re/ labeling/ SPECT分类
医药卫生引用本文复制引用
锁耀宇,杨卫东,马晓伟,汪静..NGR短肽的188Re标记及其在荷瘤裸鼠体内的生物分布和SPECT显像[J].同位素,2011,24(2):77-82,6.基金项目
国家自然科学基金资助项目(30770598,30970846) （30770598,30970846）
