实用临床医药杂志2011，Vol.15Issue(13)：15-17,3.
腹腔内灌注重组人p53腺病毒注射液及顺铂结合局部亚高温热疗治疗恶性腹水观察
Early efficacy study of intraperitoneal Ad-p53 and cisplatin in combination with regional thermotherapy in malignant ascites
秦苑 1任东 2范宇飞 2刘晓林 2李定纲1
作者信息
- 1. 北京市海淀医院,肿瘤血液科,北京,100080
- 2. 北京燕化医院,肿瘤科,北京,102500
- 折叠
摘要
Abstract
Objective To evaluate the effects of intraperitoneal recombinant adenovirus p53 injection (rAd- p53) and cisplatin combined with regional thermotherapy on malignant peritoneal effusion. Methods Fifty patients with malignant ascites were treated in different groups as below:25 patients were given intracavitary administration of rAd - p53 1 × 1012 VP after ascites drainage,48～72 h later cisplatin 40 mg/m2 was given by intraperitoneal injection weekly. Then 1 h of radio frequency thermotherapy (RFT) on abdomen followed, and RFT was operated twice a week. The treatment was repeated for 4 weeks. The other 25 patients just got cisplatin 40 mg/m2 intraperitoneal infusion after ascites drainage weekly and 1 h of abdominal regional RFT twice a week for 4 weeks. Results The overall response rate (CR + PR + SD) of 2 groups were 88.0 ％ and 64.0 ％ (P ＜0.05). The toxicity of rAd- p53 was transient fever, and the adverse reaction of RFT was transient subcutaneous scleroma. No grade Ⅲ or grade Ⅳ toxic reactions were found. Conclusion It is safe and effective to treat malignant ascites with intraperitoneal Ad - p53 and cisplatin in combination with abdominal regional RFT.关键词
重组人p53腺病毒注射液/恶性体腔积液/基因治疗/局部射频热疗Key words
recombinant human p53 adenovirus injection/ malignant ascites/ gene therapy/ radio frequency thermotherapy分类
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秦苑,任东,范宇飞,刘晓林,李定纲..腹腔内灌注重组人p53腺病毒注射液及顺铂结合局部亚高温热疗治疗恶性腹水观察[J].实用临床医药杂志,2011,15(13):15-17,3.
